Cytoplasmic nucleic acid sensors
WebThe cGAS – STING pathway acts to detect cytosolic DNA and induce an immune response. Upon binding DNA, the protein cyclic GMP-AMP Synthase ( cGAS) triggers … WebJan 1, 2024 · Indeed, several cytosolic sensors in the family of NLRs such as NOD2, NLRP3, NLRP6, and NLRP12 have been shown to play a central role in intestinal homeostasis and their defects are associated with colitis and colitis-associated colorectal cancer ( Elinav et al., 2011; Hugot et al., 2001; Udden et al., 2024; Zaki et al., 2010, Zaki …
Cytoplasmic nucleic acid sensors
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WebMay 30, 2024 · Mitochondrial DNA (mtDNA) is a potent agonist of the cyclic GMP-AMP (cGAMP) synthase (cGAS) – Stimulator of Interferon Genes (STING) – type I interferon (IFN-I) pathway. However, the kinetics of mtDNA detection by cGAS or other nucleic acid sensors and the exact immunostimulatory features of mtDNA remain poorly defined. … Webrecognize pathogen-derived nucleic acids are present in vesicular compartments and in the cytosol of most cell types. Here, we review recent studies of these cyto-solic sensors, …
WebOct 28, 2024 · The authors also suggested that as well as acting as a downstream sensor of cytoplasmic mtDNA, NLRP3 also contributes to mtDNA release by facilitating mPTP formation in the mitochondria inner membrane (Nakahira et al., 2011). ... L1 cDNA accumulates in the cytoplasm in aging and disease, where it is sensed by nucleic acid … WebJun 28, 2012 · Recently, some new sensors for viral RNA or DNA have been reported, such as HMGBs, IFI16, IFIT1, and DDX41 (16, 17, 32, 33). These molecules recognize different types of nucleic acids or function in different cell types. Despite the progress in recent years, how viral nucleic acids are recognized by host cells is still enigmatic.
WebSep 4, 2012 · Our results suggest that only the type of amyloid-containing nucleic acids is capable of inducing IFN-I through activating nucleic acid-sensing TLRs. Interestingly, protein misfolding products display another innate immune function: both fibrillar Aβ and amyloid precursor of islet amyloid polypeptide potently activate NALP3 inflammasome … WebFrom the reviews: "This book consists of 15 chapters contributed by experts in the field of functional nucleic acids, mostly in the area of specific analytical applications of nucleic acids ... . this book affords a comprehensive collection of clearly presented, up-to-date reviews that broadly cover the numerous applications of functional nucleic acids. ...
WebMar 29, 2024 · In recent years, increasing research works are pushing the limit of nucleic acid sensors in preclinical applications and imaging-guided therapy. However, the applicability of current nucleic acid sensors in vivo is largely hindered by the complexity of living animals. ... Since APE1 is only present in the cytoplasm of inflammatory cells but …
WebEmergence evidence revealed that nucleic acid receptors sense cytoplasmic RNA or DNA produced by chemotherapy, radiation therapy or DNA damage. ... The cytosolic nucleic acid sensor LRRFIP1 ... iphone power off buttonWebcGAS is a cytoplasmic nucleic acid sensor with the widest recognition ability for double-stranded DNA (dsDNA); it binds dsDNA in a manner independent of sequence specificity . cGAS can also recognize other types of nucleic acids that trigger other important functions dependent on its subcellular location. The classic function of cGAS is to ... orange county mediation lawyerWebSep 1, 2024 · TLR8, and TLR9. 1 The cytoplasmic nucleic acids are mainly recog- ... (ZBP1; also known as DAI or DLM-1) is a nucleic acid sensor that contains two Zα … iphone power on problemWebCytoplasmic nucleic acid sensors in antiviral immunity. The innate immune system uses pattern recognition receptors (PRRs) to sense invading microbes and initiate a rapid … iphone power off not workingWebSep 1, 2024 · Innate sensors recognize pathogen‐associated molecular patterns (PAMPs) or damage‐associated molecular patterns (DAMPs) to initiate innate immune response by activating downstream signaling.... iphone power save modeWebThe best studied cytoplasmic nucleic acid sensors are RNA sensors. These include PKR and members of the family of retinoic acid-inducible gene I (RIG-I)-like helicases (RLHs), which detect single- and double-stranded viral RNA. orange county medical hospitalsWebEnrichment of Zα domains at cytoplasmic stress granules is due to their innate ability to bind nucleic acids: Author: Luisa Gabriel Bharath Srinivasan Krzysztof Kus Alekos Athanasiadis : DOI: 10.1101/2024.01.20.427402: Comments: Category: Subjects orange county medical examiner orlando fl