site stats

Carfilzomib maintenance after transplant

WebMar 22, 2013 · This phase II trial studies how well carfilzomib, lenalidomide, and dexamethasone before and after stem cell transplant works in treating patients with newly diagnosed multiple myeloma. Carfilzomib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. WebFeb 3, 2024 · Dytfeld D, Wróbel T, Jamroziak K, et al. Carfilzomib, lenalidomide, and dexamethasone or lenalidomide alone as maintenance therapy after autologous stem-cell transplantation in patients with ...

Post-Transplant Maintenance Treatment Options in …

WebWayne Kuznar. Orlando, FL—A conditioning regimen before autologous hematopoietic stem-cell transplant (HSCT) consisting of carfilzomib (Kyprolis) plus high-dose … WebObjective: We investigated the efficacy and safety of carfilzomib-containing induction before salvage high-dose melphalan with autologous stem-cell transplantation (salvage ASCT) and maintenance with carfilzomib and dexamethasone after salvage ASCT in multiple myeloma. Methods: This randomised, open-label, phase 2 trial included patients … scotchie\\u0027s custom cakes https://glammedupbydior.com

Isatuximab, carfilzomib, lenalidomide, and dexamethasone (Isa ... - Nature

WebJan 27, 2024 · Phase 3 trial results support the use of carfilzomib, lenalidomide, and dexamethasone as maintenance after autologous stem cell transplant in patients with multiple myeloma, according to researchers. Results from the ATLAS trial showed that carfilzomib plus lenalidomide and dexamethasone significantly prolongs progression … WebApr 9, 2024 · before and after autologous stem-cell transplantation for newly diagnosed multiple myeloma (CASSIOPEIA): a randomised, open - label, phase 3 study. Lancet 394 , 29 – 38 (2024). WebDec 20, 2024 · Source Reference: Yong K, et al "Upfront autologous haematopoietic stem-cell transplantation versus carfilzomib–cyclophosphamide–dexamethasone consolidation with carfilzomib maintenance in ... scotchie\\u0027s custom cakes winter park

Carfilzomib/Cyclophosphamide/Dexamethasone With …

Category:Carfilzomib and dexamethasone maintenance ... - Wiley …

Tags:Carfilzomib maintenance after transplant

Carfilzomib maintenance after transplant

Carfilzomib Maintenance Improves Response Following …

WebJan 12, 2024 · report interim findings of the ATLAS study, in which they compared carfilzomib, lenalidomide, and dexamethasone with lenalidomide alone as … WebTransplant-eligible candidates received stem cell collection. Five patients continued to receive single-agent lenalidomide maintenance therapy after induction. After a median …

Carfilzomib maintenance after transplant

Did you know?

WebJun 12, 2024 · Detailed Description: This is a phase II study to evaluate the efficacy of once weekly carfilzomib, lenalidomide, dexamethasone, and isatuximab (KRDI) in patients with newly diagnosed, transplant-eligible multiple myeloma. The research study procedures include screening for eligibility and study treatment including evaluations and follow up ... WebA common strategy to address this is to switch to an alternate-week schedule as “maintenance”, usually after 8–9 cycles of full-intensity therapy. 43 Using this approach, carfilzomib is administered on days 1, 2, 15, and 16 of each 4-week maintenance cycle. An alternative to this has been the development of weekly carfilzomib therapy.

WebMar 28, 2024 · Thirty-five years after the introduction of high dose melphalan (HDM) followed by autologous stem cell transplantation (ASCT) as a treatment strategy for multiple myeloma (MM) [1,2,3], ASCT ... WebFeb 21, 2024 · Costa LJ, Landau HJ, Chhabra S, Hari P, Innis-Shelton R, Godby KN, et al. Phase 1/2 trial of carfilzomib plus high-dose melphalan preparative regimen for salvage …

WebApr 8, 2024 · Median DOR was 9.3 months and median PFS 7.5 months. As for safety, grade ≥ 3 CRS was reported in less than 3% of patients and grade ≥ 3 infections in about 17%. The novel toxicities of this drug were skin-related, nail disorders and dysgeusia occurring in 56%, 52% and 48% of patients, respectively [ 196, 197 ]. WebSep 1, 2015 · His medical history was significant for immunoglobulin A (IgA) κ MM treated with hematopoietic autologous stem cell transplantation (HSCT) 3 years earlier. At the time of presentation, the patient was receiving maintenance chemotherapy with lenalidomide to help extend clinical remission.

WebMar 16, 2024 · Finally, we performed a multivariate analysis that included use of maintenance, early vs. delayed transplant, ASCT before vs. after 2007, high vs. SR FISH and ISS stage 3 vs. 1 and 2 and found all ... scotchie\u0027s custom cakes winter parkWebAbstract. Objective: We investigated the efficacy and safety of carfilzomib-containing induction before salvage high-dose melphalan with autologous stem-cell transplantation … scotchie\u0027s st. ann’s bayWebCarfilzomib comes as a powder to be mixed with liquid to be injected intravenously (into a vein). Carfilzomib is given by a doctor or nurse in a medical office or clinic usually over a … scotchildcare